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Although the spinal trigeminal nucleus (STN) has been considered to be a nuclear group, only limited data exist about the exact neuronal subpopulations. Here, the aim of the present study was to show the topographical relationships between the somatotopically defined STN components. Therefore, in this study the neuronal elements of the human STN were compared in an ultrastructural analysis and were evaluated morphometrically. Serial vibratome sections from five postnatal human fetuses (13-20 weeks old, E47-E83) and from three infants (one week, five and seven months old, respectively, E46-E63), were analyzed. The following findings were obtained: (1) In the STN, the neuropil is comprised of three different types of synaptic terminals: (a) the symmetrical synapse, (b) the synapse in the unlabeled gap junction and (c) the synapse in the unlabeled synaptic cleft. The immature neuropil showed synaptic terminals of the same type in the same localization as in the adult. (2) The neurons of the nuclear gray matter displayed different types of dendritic spines. The spinous synapses were most abundant. (3) In addition to a low-immature spinous synapse, large synaptic complexes with the features of spinodendritic synapses were present. (4) Neurons with spinelike processes were present. (5) In the cytoplasm, the dendritic spines were indistinguishable from those of the adult and only the synapses at the proximal part of the dendritic shafts appeared immature. (6) The somata of some neurons were relatively large with a lot of dendritic spines in the perikaryal space. (7) Due to the ultrastructural findings, the following neuronal types can be distinguished: (a) the small neuron with a large nucleus, (b) the interneuron and (c) the small neuron with a small nucleus. Due 0b46394aab
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